Calcitonin gene-related peptide CGRP immunoreactive projections from the thalamus to the striatum and amygdala in the rat. Physiology of penile erection and pathophysiology of erectile dysfunction. Elevated levels of PRL and serotonin after orgasm have been suggested as a potential cause; however, there is much debate about their exact role Afferent connections of the parvocellular subparafascicular thalamic nucleus in the rat: Figure 2 summarizes the reflex circuit necessary to elicit ejaculation.
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FUNCTIONAL ANATOMY OF THE MALE GENITAL ORGANS

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The exact trigger for expulsion is unknown. The effect on erection and orgasm of cystectomy, prostatectomy and vesiculectomy for cancer of the bladder: Data in humans are still too preliminary to draw final conclusions, and further research is needed. Effects of discrete lesions of the sexually dimorphic nucleus of the preoptic area or other medial preoptic regions on the sexual behavior of male rats. Becomes the vas deferens at the end of the tail. Brain network Sensory and motor areas in the brain play an important role in the ejaculation, which requires a highly coordinated and integrated central process.
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Parasympathetic supply to the penis is derived from the sacral segments S2-S4 J Clin Endocrinol Metab. Orgasm is an intense transient peak sensation of intense pleasure creating an altered state of consciousness associated with reported physical changes. Early orgasms are less satisfying than later orgasms in life as the person learns to accept the pleasure associated with orgasms. The nPGI nucleus likely plays an inhibitory role in ejaculation as evidenced through the urethrogenital reflex experimental model, a rat model for the expulsion phase of ejaculation 73 , Springer Science; New York:
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In addition, we describe the neurochemical and hormonal regulation of the ejaculation process. Despite the many published research projects dealing with the physiology of orgasm and ejaculation, much about this topic is still unknown. Sexual differentiation of the brain and behavior. Although hypercortisolism in men was associated with reduced libido, no effect was identified on orgasm or ejaculation Localization of vasoactive intestinal polypeptide in penile erectile tissue and in the major pelvic ganglion of the rat. The identification of a brainstem site controlling spinal sexual reflexes in male rats. Human sexual response.
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